Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

Interleukin-21 Enhances NK Cell Activation

Splenocyte proliferation, NK cell activation and cytokines production by extract of Scrophularia variegata; an in vitro study on mice spleen cells

Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of S.  variegata. Methods: The splenocytes were harvested...

Effect of Soluble HLA Class I Molecule on NK/LAK Cells Activation Induced by Poly I:C

Background:  Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules.  These receptors could induce signals that determine NK cells ability to mediate cytotoxicity.  Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective:  To evaluate the influence of sHLA and two monoclonal an...

Production and NK Cell Activation Interleukin-12 and Gamma Interferon Mice Is Associated with Differences in Expression between BALB/c and C57BL/6 Variation in Adenovirus Transgene

Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation.

The innate immune response against replication-defective adenoviruses (Ad) is poorly defined. We and others have previously observed striking differences in the rate at which the Ad vector itself or the virus encoding a variety of transgenes is eliminated in different mouse strains. Here, we report that Ad infection of BALB/ mice is associated with sixfold-higher levels of serum alanine aminotr...